Ca2+ is the preeminent second messenger in excitable organs including the central nervous system.

A 10,000 fold concentration gradient from the extracellular to the intracellular compartment is guaranteed by the presence of cytoplasmic Ca2+ binding proteins that bind Ca2+ with rapid kinetics. We are interested in resolving the true Ca2+ binding dynamics of key intracellular Ca2+ binding and regulatory proteins, including calmodulin, calbindin, parvalbumin, calretinin and others. The differential distribution of these Ca2+ binding proteins in neurons and glia cells and their specific changes during neurological and psychiatric disorders may render these proteins as exciting targets for future therapeutic interventions. Our method established for determining the dynamics of Ca2+ binding to these proteins is a key step towards developing strategies to alter Ca2+ dependent second messenger cascades in the nervous system and other  tissues, such as muscle cells or lung cancer cells.

Current projects at the Modylab involving Ca2+ binding Proteins

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