We presently concentrate our efforts on epilepsies, Alzheimer’s disease and depression and our goal is to provide fundamental insights for the development of novel therapies for these devastating disorders.
One of our recent translational success stories is the development of the first treatment of postpartum depression based on our studies in mice (Maguire and Mody, Neuron 2008). A common thread in our research is the study of GABA ergic inhibition in the brain and changes in Ca2+ dependent control of excitability.
We use translationaly valid mouse models of human neurological and psychiatric disorders including a model of temporal lobe epilepsy that replicates the human condition, a humanized mouse model of Alzheimer’s disease and mouse models of reproductive depression prevalent in women. Our techniques range from single channel, single neuron, neuronal network recordings using patch-clamp, optical recordings, local field potential analysis, optogenetics, chemogenetics and targeted viral expression. On a single molecule level we can measure the Ca2+ binding kinetics of Ca2+ to Ca2+ binding proteins under physiological conditions. We are constantly developing novel methods of analysis that provide unprecedented insights into single neuron and network function. We are one of the few laboratories that record both in vivo and in vitro from mice aged >2 years, equivalent to human age>75 years. This has enabled us to gain unprecedented insight into processes of normal and pathological aspects of aging.